Using a drawing tablet as a mouse replacement
If your are a creative, then it's pretty obvious why there's a benefit to using a drawing tablet instead of a mouse when you are drawing.
But some people, simply want to use the drawing tablet as a mouse replacement in general.
My personal experience
I did this for about 10 years. Although I always had a mouse connected, 99.9% of the time I used a drawing tablet.
Size
I used a MEDIUM sized tablet - something the size of a Wacom Intuos Pro Medium.
For a few years I a SMALL sized tablet - something the size of a Wacom Intuos Pro small. When I was using the small tablet, I was in a non-artistic phase so I was not drawing with it much.
Ergonomics
One of the reasons I avoided using the mouse was that it was causing wrist pain.
The pen was helpful in reducing the pain. However, if I do draw a lot over a month or so, I can develop wrist pain.
Holding the pen while typing
To make it easier to switch between typing and using the pen I ALWAYS held the pen in my hand even when typing.
When drawing I held it like you would normally hold a pen, but when I switched to typing, as I extended out my fingers the pen I would rotate the pen so the tip is pointing up and to the side.
Other experiences
Here's a detailed write up of someone's experience: (https://www.reddit.com/r/wacom/comments/136u00y/replacing_your_mouse_with_a_drawing_tabletpen/)
Tablets that would work well as a mouse replacement
Lots of them would work. The easy choices are:
One for Wacom Small CTL-472
One for Wacom Medium CTL-672
Wacom Intuos Small CTL-4100
Wacom Intuos Medium CTL-6100
Generally, I would suggest a medium size, though small can work also.
Videos
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